Khamnei S, Robbins P A
University Laboratory of Physiology, Oxford, U.K.
Respir Physiol. 1990 Jul;81(1):117-34. doi: 10.1016/0034-5687(90)90074-9.
The ventilatory responses of 5 volunteers to three protocols were determined. In protocol A, PETCO2 was held at 1-2 Torr above resting; and PETO2 at 100 Torr for 10 min, 50 Torr for 20 min, and 100 Torr again for 10 min. In protocol B, PETCO2 was held at 8 Torr above resting, and PETO2 varied as in protocol A. Protocol C formed a control. Each protocol was repeated at least 6 times on each subject. The data were used to evaluate four different models (models 2-5) for incorporating the depressant effect of hypoxia into a standard model (model 1) of the chemoreflex responses. In model 2, hypoxic depression was incorporated as an additive term independent of the central and peripheral chemoreflexes; in model 3 it affected the central chemoreflex gain; in model 4 it affected the peripheral chemoreflex gain; and in model 5 it affected the gain of both reflexes. From this, it was concluded only model 4 was consistent with the data; all other models were inconsistent.
测定了5名志愿者对三种方案的通气反应。在方案A中，呼气末二氧化碳分压（PETCO2）维持在比静息值高1 - 2托；呼气末氧分压（PETO2）在100托维持10分钟，50托维持20分钟，然后再次在100托维持10分钟。在方案B中，PETCO2维持在比静息值高8托，PETO2的变化与方案A相同。方案C作为对照。每个方案在每个受试者身上至少重复6次。这些数据被用于评估四种不同的模型（模型2 - 5），以便将低氧的抑制作用纳入化学反射反应的标准模型（模型1）中。在模型2中，低氧抑制作为一个独立于中枢和外周化学反射的附加项纳入；在模型3中，它影响中枢化学反射增益；在模型4中，它影响外周化学反射增益；在模型5中，它影响两个反射的增益。由此得出结论，只有模型4与数据一致；所有其他模型均不一致。
