Clement I D, Bascom D A, Conway J, Dorrington K L, O'Connor D F, Painter R, Paterson D J, Robbins P A
University Laboratory of Physiology, Oxford, U.K.
Respir Physiol. 1992 Apr-May;88(1-2):87-100. doi: 10.1016/0034-5687(92)90031-q.
The independence of the central and peripheral chemoreflexes has been tested in humans. Acute metabolic acidosis generated by a prior bout of brief, hard exercise was used to stimulate primarily the peripheral chemoreceptors, and respiratory acidosis generated by inhaled CO2 was used to stimulate both central and peripheral chemoreceptors. Seven healthy young men were studied. Ventilation and arterial pH, PCO2 and PO2 were recorded. Peripheral chemoreflex sensitivity to hypoxia during acute metabolic acidosis was repeatedly determined by measuring ventilation in euoxia (PETO2 = 100 Torr) and hypoxia (PETO2 = 50 Torr) as the subject recovered from exercise-induced acidosis. Peripheral chemoreflex sensitivity to hypoxia during CO2 inhalation was repeatedly determined by measuring ventilation in euoxia and hypoxia at two levels of hypercapnia (PETCO2 = 45 Torr and PETCO2 = 50 Torr). The ventilatory sensitivity to hypoxia at matched arterial pH values was not significantly different between conditions of high (CO2 inhalation) and low (metabolic acidosis) central chemoreceptor activity. We therefore conclude that interaction between central and peripheral chemoreflexes was non-significant in all subjects.
已在人体中测试了中枢和外周化学反射的独立性。通过先前一阵短暂剧烈运动产生的急性代谢性酸中毒主要用于刺激外周化学感受器，而吸入二氧化碳产生的呼吸性酸中毒则用于刺激中枢和外周化学感受器。对7名健康年轻男性进行了研究。记录了通气量以及动脉血pH值、PCO₂和PO₂。在受试者从运动诱发的酸中毒中恢复时，通过测量常氧（PETO₂ = 100托）和低氧（PETO₂ = 50托）状态下的通气量，反复测定急性代谢性酸中毒期间外周化学反射对低氧的敏感性。通过在两种高碳酸血症水平（PETCO₂ = 45托和PETCO₂ = 50托）下测量常氧和低氧状态下的通气量，反复测定吸入二氧化碳期间外周化学反射对低氧的敏感性。在高（吸入二氧化碳）和低（代谢性酸中毒）中枢化学感受器活动状态下，匹配动脉血pH值时对低氧的通气敏感性无显著差异。因此我们得出结论，在所有受试者中，中枢和外周化学反射之间的相互作用不显著。
