中缝背核中5-羟色胺能神经元在睡眠调节中的作用
[Role of serotonergic neurons in dorsal raphe nuclei in regulation of sleep].
作者信息
Zhao Le-zhang, Zhang Gong-liang, Gao Jun, Zhang Jing-xing, Zhong Ming-kui, Zhang Jing
机构信息
Department of Physiology, Anhui Medical University, Hefei 230032, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2003 May;19(2):175-8.
AIM
To investigate the roles of serotonergic neurons in dorsal raphe nuclei (DRN) in sleep.
METHODS
Stereotaxic, microinjection and polysomnography (PSG) were used in the experiment.
RESULTS
Microinjection of L-glutanate (L-Glu) into the DRN decreased slow wave sleep (SWS) and paradoxical sleep (PS), and increased wake (W). Microinjection of kainic acid (KA) and p-chlorophenylalanine (PCPA) respectively into the DRN, SWS and PS were promoted, and W was reduced.
CONCLUSION
Serotonergic neurons in dorsal raphe nuclei involved in the regulation of sleep. Sleep was reduced when the serotonergic neurons were excited, and when the neurons were inhibited. sleep was increased
目的
研究中缝背核（DRN）中5-羟色胺能神经元在睡眠中的作用。
方法
实验采用立体定位、微量注射和多导睡眠图（PSG）技术。
结果
向DRN微量注射L-谷氨酸（L-Glu）可减少慢波睡眠（SWS）和异相睡眠（PS），增加觉醒（W）。分别向DRN微量注射 kainic 酸（KA）和对氯苯丙氨酸（PCPA）可促进SWS和PS，减少W。
结论
中缝背核中的5-羟色胺能神经元参与睡眠调节。5-羟色胺能神经元兴奋时睡眠减少，神经元受抑制时睡眠增加 。
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