Cao X S, Wu X Y, Wu Y H, Sun B, Zhang L N, Zhang L F
Faculty of Aerospace Medicine, Fourth Military Medical University, Xi'an 710032, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2001 Nov;17(4):392-5.
To explore the effects of three intermittent artificial gravity on simulated weightlessness rats.
30 male SD rats were divided into 5 groups: control group (C), tail-suspension group (S) and standing group (G1), 1.5 G group (G2), 2.6 G (G3) group; randomly and equally. G groups were given 1 h/d standing, 1.5 G or 2.6 G artificial gravity each day. The effects of 3 weeks artificial gravity on tail-suspension rats were evaluated by measuring physical and mechanical parameters of femur.
Compared to S rats, elastic ultimate load (EUL), the ultimate load (UL) and bending rigidity coefficient (BRC) of G1 rats (P < 0.05) improved significantly; Diameter (P < 0.01), mass (dry) and density (P < 0.05), EUL and UL (P < 0.05) of G2 rats raised significantly; EUL and UL of G3 rats (P < 0.01) improved markedly.
By using intermittent artificial gravity, the mechanical parameters of weight loading bones of simulated weightlessness rats were all improved apparently, and the one using 1.5 G 1 h/d artificial gravity was the best.
探讨三种间歇性人工重力对模拟失重大鼠的影响。
将30只雄性SD大鼠随机等分为5组：对照组（C）、尾吊组（S）、站立组（G1）、1.5G组（G2）、2.6G组（G3）；G组每天给予1小时的站立、1.5G或2.6G人工重力。通过测量股骨的物理和力学参数来评估3周人工重力对尾吊大鼠的影响。
与S组大鼠相比，G1组大鼠的弹性极限载荷（EUL）、极限载荷（UL）和弯曲刚度系数（BRC）显著提高（P<0.05）；G2组大鼠的直径（P<0.01）、干质量和密度（P<0.05）、EUL和UL（P<0.05）显著升高；G3组大鼠的EUL和UL显著改善（P<0.01）。
采用间歇性人工重力可明显改善模拟失重大鼠负重骨骼的力学参数，其中每天给予1小时1.5G人工重力的效果最佳。
