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巨噬细胞移动抑制因子（MIF）多态性与肺炎链球菌性脑膜炎风险的关联。

Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae.

机构信息

Department of Internal Medicine, Yale University School of Medicine, The Anlyan Center, S525, P.O. Box 208031, 300 Cedar Street, New Haven, CT 06520-8031, USA.

出版信息

Cytokine. 2011 Mar;53(3):292-4. doi: 10.1016/j.cyto.2010.12.010. Epub 2011 Jan 3.

DOI:10.1016/j.cyto.2010.12.010
PMID:21208809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3033983/
Abstract

Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.

摘要

巨噬细胞移动抑制因子（MIF）是一种上游促炎细胞因子，由一个具有功能多态性的基因座编码。这项对 119 名患者的研究探讨了 MIF 基因型与侵袭性肺炎链球菌感染之间的潜在关系。我们观察到一种高表达 MIF 等位基因与肺炎球菌性脑膜炎发生之间存在关联。

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本文引用的文献

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Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models.层粘连蛋白受体在实验性脑膜炎模型中启动细菌与血脑屏障的接触。
J Clin Invest. 2009 Jun;119(6):1638-46. doi: 10.1172/JCI36759. Epub 2009 May 11.
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The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia.巨噬细胞移动抑制因子基因多态性对社区获得性肺炎预后的影响。
FASEB J. 2009 Aug;23(8):2403-11. doi: 10.1096/fj.09-129445. Epub 2009 Apr 3.
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Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion.巨噬细胞迁移抑制因子的缺失通过限制病毒神经侵袭降低西尼罗河病毒致死率。
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Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma.巨噬细胞移动抑制因子启动子多态性与硬皮病的临床表型
Arthritis Rheum. 2006 Nov;54(11):3661-9. doi: 10.1002/art.22179.
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Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor.类风湿关节炎严重程度与巨噬细胞移动抑制因子的基因功能变异及循环水平的相关性
Arthritis Rheum. 2005 Oct;52(10):3020-9. doi: 10.1002/art.21285.
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Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism.囊性纤维化、疾病严重程度与巨噬细胞移动抑制因子多态性
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Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies.利用薄膜生物传感器芯片同时检测巨噬细胞移动抑制因子（MIF）基因中的微卫星重复序列和单核苷酸多态性及其在农村现场研究中的应用
Nucleic Acids Res. 2005 Aug 2;33(13):e121. doi: 10.1093/nar/gni123.
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Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis.巨噬细胞移动抑制因子基因 -173 多态性在全身型幼年特发性关节炎中的功能及预后相关性
Arthritis Rheum. 2003 May;48(5):1398-407. doi: 10.1002/art.10882.
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Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator.巨噬细胞移动抑制因子呈现出明显的昼夜节律，这与其作为糖皮质激素反调节因子的作用相关。
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A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis.巨噬细胞移动抑制因子（MIF）基因中的一个功能性启动子多态性与类风湿关节炎的疾病严重程度相关。
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