Laboratoire UPRES EA 27-10 "Radiosensibilité des Tumeurs et Tissus Sains", Institut Gustave Roussy, 39 rue Camille Desmoulins, 94800 Villejuif, France.
J Oncol. 2011;2011:549181. doi: 10.1155/2011/549181. Epub 2010 Dec 16.
Lung cancer remains the leading cause of cancer death. Understanding lung tumors physiopathology should provide opportunity to prevent tumor development or/and improve their therapeutic management. Cancer stem cell (CSC) theory refers to a subpopulation of cancer cells, also named tumor-initiating cells, that can drive cancer development. Cells presenting these characteristics have been identified and isolated from lung cancer. Exploring cell markers and signaling pathways specific to lung CSCs may lead to progress in therapy and improve the prognosis of patients with lung cancer. Continuous efforts in developing in vitro and in vivo models may yield reliable tools to better understand CSC abilities and to test new therapeutic targets. Preclinical data on putative CSC targets are emerging by now. These preliminary studies are critical for the next generation of lung cancer therapies.
肺癌仍然是癌症死亡的主要原因。了解肺癌的病理生理学应该为预防肿瘤发展或/和改善其治疗管理提供机会。癌症干细胞 (CSC) 理论是指一小部分癌细胞，也称为肿瘤起始细胞，它们可以驱动癌症的发展。已经从肺癌中鉴定和分离出具有这些特征的细胞。探索肺 CSCs 特有的细胞标志物和信号通路可能会促进治疗进展并改善肺癌患者的预后。不断努力开发体外和体内模型可能会产生可靠的工具，以更好地了解 CSC 的能力并测试新的治疗靶点。目前已经出现了针对潜在 CSC 靶点的临床前数据。这些初步研究对于下一代肺癌治疗至关重要。
