Kuhn M J, Baker M R
Department of Radiology, St. John's Hospital, Southern Illinois University School of Medicine, Springfield 62769.
AJNR Am J Neuroradiol. 1990 Sep-Oct;11(5):847-9; discussion 850-1.
A prospective, randomized, double-blind comparative study of 200 patients was made to examine the image quality, safety, and costs of 100 ml of ioversol-320 (32 g iodine) and 150 ml of iohexol-300 (45 g iodine) in patients undergoing cranial CT. We found no statistically significant difference in image quality between the two low-osmolality, nonionic contrast agents at these doses. There was a statistically significant (p = .02) difference in the occurrence of minor to mild adverse effects caused by ioversol (n = 0) as compared with iohexol (n = 5). No patient in either group experienced any major contrast-induced reactions. Contrast media costs were 34% less in patients receiving 32 g of iodine as compared with those receiving 45 g of iodine. This study demonstrates that high-quality cranial CT scans are possible even with a reduced volume of low-osmolality contrast medium, and that the potential cost savings are significant.
对200例患者进行了一项前瞻性、随机、双盲对照研究，以检查100ml碘海醇-320（32g碘）和150ml碘克沙醇-300（45g碘）用于颅脑CT检查时的图像质量、安全性及成本。我们发现，在这些剂量下，两种低渗非离子型对比剂的图像质量无统计学显著差异。碘海醇（n = 0）与碘克沙醇（n = 5）相比，在轻微至轻度不良反应的发生率上存在统计学显著差异（p = 0.02）。两组均无患者发生任何严重的对比剂诱发反应。接受32g碘的患者与接受45g碘的患者相比，对比剂成本降低了34%。本研究表明，即使减少低渗对比剂的用量，高质量的颅脑CT扫描也是可行的，且潜在的成本节约显著。
