酯酶不稳定的磺酸酯保护基的设计与应用。
Design and application of esterase-labile sulfonate protecting groups.
机构信息
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St., Worcester, MA 01605, USA.
出版信息
Chem Commun (Camb). 2011 Feb 21;47(7):2038-40. doi: 10.1039/c0cc04796a. Epub 2011 Jan 5.
PMID:21210039
Abstract
Three esterase-labile, but chemically-stable sulfonate protecting groups have been designed and synthesized. One of these sulfonate esters allowed the cytoplasmic delivery and unmasking of a sulfonated dye in live cells.
摘要
三种酯基不稳定但化学稳定的磺酸酯保护基团已经被设计和合成。其中一种磺酸酯可以在活细胞中实现磺酸染料的细胞质内递送和去保护。
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