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Specificity of esterases and structures of prodrug esters. III. Activity of rat tissue homogenates, rat plasma and porcine liver esterase for the hydrolysis of 3',5'-bis-dicarboxylic acid hemiesters of 5-fluoro-2'-deoxyuridine.

作者信息

Kawaguchi T, Suzuki Y, Nambu N, Nagai T

出版信息

Chem Pharm Bull (Tokyo). 1985 Jul;33(7):2956-61. doi: 10.1248/cpb.33.2956.

DOI:10.1248/cpb.33.2956
PMID:2935265
Abstract
摘要

相似文献

1
Specificity of esterases and structures of prodrug esters. III. Activity of rat tissue homogenates, rat plasma and porcine liver esterase for the hydrolysis of 3',5'-bis-dicarboxylic acid hemiesters of 5-fluoro-2'-deoxyuridine.酯酶的特异性及前药酯的结构。III. 大鼠组织匀浆、大鼠血浆和猪肝酯酶对5-氟-2'-脱氧尿苷3',5'-双二羧酸半酯的水解活性。
Chem Pharm Bull (Tokyo). 1985 Jul;33(7):2956-61. doi: 10.1248/cpb.33.2956.
2
Specificity of esterases and structure of prodrug esters. II. Hydrolytic regeneration behavior of 5-fluoro-2'-deoxyuridine (FUdR) from 3',5'-diesters of FUdR with rat tissue homogenates and plasma in relation to their antitumor activity.酯酶的特异性与前药酯的结构。II. 5-氟-2'-脱氧尿苷（FUdR）3',5'-二酯在大鼠组织匀浆和血浆中的水解再生行为及其与抗肿瘤活性的关系
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3
Activity of esterase in the hydrolysis of 3',5'-diesters of 5-fluoro-2'-deoxyuridine in relation to the structure of the diester prodrugs.酯酶在5-氟-2'-脱氧尿苷3',5'-二酯水解中的活性与二酯前药结构的关系
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Hydrolysis of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) in rabbit and human plasma and its release from oily solution.
J Pharmacobiodyn. 1989 Aug;12(8):495-502. doi: 10.1248/bpb1978.12.495.
6
Terbium(III) Luminescence-Based Assay for Esterase Activity.基于铽(III)发光的酯酶活性测定法。
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7
Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes.评估α-氰基酯作为荧光底物用于检测人肝微粒体中一般酯酶和拟除虫菊酯选择性酯酶的个体间差异。
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Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver.人、小型猪和大鼠皮肤及肝脏对普鲁卡因和酯水解的特异性。
Drug Metab Dispos. 2007 Nov;35(11):2015-22. doi: 10.1124/dmd.107.015727. Epub 2007 Jul 30.
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3',5'-Diesters of 5-fluoro-2'-deoxyuridine and thymidine: hydrolysis by esterases in human, mouse, and insect tissue.5-氟-2'-脱氧尿苷和胸苷的3',5'-二酯：在人、小鼠和昆虫组织中被酯酶水解
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Nonenzymatic and enzymatic hydrolysis of 5-fluoro-2'-deoxyuridine (FUdR) esters.5-氟-2'-脱氧尿苷（FUdR）酯的非酶促水解和酶促水解
Pharm Res. 1988 Nov;5(11):741-4. doi: 10.1023/a:1015972214747.

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Diesterified derivatives of 5-iodo-2'-deoxyuridine as cerebral tumor tracers.5-碘-2'-脱氧尿苷的二酯化衍生物作为脑肿瘤示踪剂。
PLoS One. 2014 Jul 16;9(7):e102397. doi: 10.1371/journal.pone.0102397. eCollection 2014.