细胞内不透膜磺酸盐的光激活释放。
Photoactivated release of membrane impermeant sulfonates inside cells.
机构信息
School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
出版信息
Chem Commun (Camb). 2021 Apr 25;57(32):3917-3920. doi: 10.1039/d0cc07713e. Epub 2021 Mar 23.
Abstract
Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.
摘要
光解笼技术可实现对生物过程的诱导或抑制，具有高时空控制的化合物的释放，但释放的化合物可能会扩散出去。我们在这里证明了磺酸根阴离子可以被光解笼，这样一种膜不可渗透的化合物就可以进入细胞，通过光辐照解笼，并被困在细胞内。
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