Vinchon Matthieu
Department of Pediatric Neurosurgery, University Hospital, Lille, France.
Childs Nerv Syst. 2011 Mar;27(3):463-4. doi: 10.1007/s00381-010-1361-1. Epub 2011 Jan 6.
We review a paper by Dr. Salman on the role and timing of posterior fossa decompression in Chiari 2 malformation (C2M) associated with myelomeningocele, based on a volumetric study of the posterior fossa in operated vs non-operated patients. This paper states that, although CSF spaces were increased after posterior fossa decompression (PFD), cerebellar atrophy was not prevented by surgery and concludes that early PFD in newborns could prevent cerebellar atrophy. In the discussion, we point at the small size of patient samples and dissimilarity of the groups, which might underscore the radiological results, and regret the lack of clinical correlation with the radiological data and of the information on the shunt status in the two groups. We conclude that the author's conclusions regarding the timing and efficiency of ultra-early PFD in patients with C2M are not supported by his data.
我们回顾了萨尔曼博士的一篇论文,该论文基于对接受手术和未接受手术患者的后颅窝容积研究,探讨了后颅窝减压术在与脊髓脊膜膨出相关的Chiari 2型畸形(C2M)中的作用和时机。该论文指出,尽管后颅窝减压术后脑脊液间隙增加,但手术并不能预防小脑萎缩,并得出结论,新生儿早期进行后颅窝减压术可预防小脑萎缩。在讨论中,我们指出患者样本量小以及两组之间的差异,这可能会突出放射学结果,并对缺乏与放射学数据的临床相关性以及两组分流状态信息表示遗憾。我们得出结论,作者关于C2M患者超早期后颅窝减压术的时机和有效性的结论并未得到其数据的支持。