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[辐照肝脏和肝癌标本的电子自旋共振光谱分析]

[Analysis of the ESR spectra of irradiated liver and hepatoma specimens].

作者信息

Pulatova M K, Rikhireva G T, Turganov M M, Burlakova E B, Pal'mina N P

出版信息

Biofizika. 1978 Sep-Oct;23(5):852-8.

PMID:212116
Abstract

The analysis of ESR low temperature spectra of in vitro gamma-irradiated (1 Mrad) liver, hepatoma 22-a and tumor host liver has been carried out. On the ground of differences in thermostability and relaxation parameters of paramagnetic centres it has been shown, that there is a large amount of different paramagnetic centres in irradiated normal and tumor tissues. The ESR spectra parameters and properties of observed paramagnetic centres are presented. The main result is the detection of a specific "tumor signal" (asymmetrical singlet deltaH = 6, Oe, g = 2.005) and peroxide radical ROO. signal in tumor and tumor host liver.

摘要

对体外γ射线辐照(1兆拉德)的肝脏、肝癌22-a及肿瘤宿主肝脏的电子自旋共振(ESR)低温光谱进行了分析。基于顺磁中心热稳定性和弛豫参数的差异表明,在辐照后的正常组织和肿瘤组织中存在大量不同的顺磁中心。给出了ESR光谱参数及所观察到的顺磁中心的性质。主要结果是在肿瘤及肿瘤宿主肝脏中检测到一种特定的“肿瘤信号”(不对称单峰,δH = 6,奥斯特,g = 2.005)以及过氧自由基ROO·信号。

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