School of Chemistry and Chemical Engineering, The State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Nanotechnology. 2011 Feb 11;22(6):065702. doi: 10.1088/0957-4484/22/6/065702. Epub 2011 Jan 7.
Photosensitive nanoparticles (NPs) were fabricated by employing chitosan hydrochloride (CHC) and photosensitive 4-oxo-4-(pyren-4-ylmethoxy) butanoic acid (PYBA) through ionic self-assembly. Transmission electron microscope (TEM) images showed that the average diameter of the complex NPs depended on the charge molar ratio of PYBA to CHC. The photosensitive properties of the NPs were investigated using (1)H NMR, optical photography, dynamic light scattering and TEM. As a model guest, Nile red dye was loaded in the photosensitive NPs. Under UV light or near infrared laser irradiation, the complex could be dissociated and shrank, so that loaded Nile red was released owing to the decomposition of chemical bonds in the photolabile chromophore groups. The results showed that 70% of the Nile red molecules were released from the NPs under a 1200 mW cm(-2) irradiation of UV light for 50 s. Moreover, the releasing rate of Nile red molecules could be adjusted by altering UV light intensity. Such a chitosan complex has potential applications in the design of photo-controlled guest delivery systems.
光敏纳米粒子（NPs）是通过壳聚糖盐酸盐（CHC）和光敏 4-氧代-4-（芘-4-基甲氧基）丁酸（PYBA）的离子自组装制备的。透射电子显微镜（TEM）图像显示，复合 NPs 的平均直径取决于 PYBA 与 CHC 的电荷摩尔比。通过（1）H NMR、光学摄影、动态光散射和 TEM 研究了 NPs 的光敏性质。以尼罗红染料为模型客体，负载于光敏 NPs 中。在紫外光或近红外激光照射下，复合物可以解离和收缩，从而由于光不稳定发色团的化学键分解，负载的尼罗红被释放。结果表明，在 1200 mW cm（-2）的紫外光照射下照射 50 s 后，有 70%的尼罗红分子从 NPs 中释放出来。此外，通过改变紫外光强度可以调节尼罗红分子的释放速率。这种壳聚糖复合物在设计光控客体传递系统方面具有潜在的应用。
