Xie Yingsi, Tuguntaev Ruslan G, Mao Cong, Chen Haoting, Tao Ying, Wang Shixiang, Yang Bin, Guo Weisheng
Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Université Paris 13, 99 avenue Jean Baptiste Clément, 93430 Villetaneuse, France.
Biophys Rep. 2020 Oct 31;6(5):193-210. doi: 10.1007/s41048-020-00117-8.
Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.
类风湿性关节炎（RA）是一种由滑膜自身免疫性疾病引发的慢性炎症性疾病。目前针对RA的治疗策略主要旨在抑制巨噬细胞的增殖并减少促炎细胞因子的产生。因此，将治疗药物积聚于炎症部位应是一种关键的治疗策略。如今，具有刺激响应特性的纳米载体系统正受到深入研究，显示出特异性治疗的潜在巨大价值。刺激响应性（如pH、温度、光、氧化还原和酶）聚合物纳米材料作为纳米颗粒载体的重要组成部分，已被广泛开发用于各种疾病的治疗。文献调查表明，在炎症性关节炎的治疗中使用靶向纳米载体递送治疗药物（纳米疗法）在很大程度上仍未得到充分探索。缺乏合适的刺激敏感聚合物纳米材料是其中一个限制因素。在此，我们概述了由常用的刺激敏感聚合物纳米材料和一些在RA治疗中具有潜力的无机试剂制备的药物递送系统。还讨论了当前的现状和挑战，以激发关于纳米医学发展的新思维。
