[超滤法测定磷酸川芎嗪血浆蛋白结合率]
[Determination of plasma protein binding rate of tetramethylpyrazine phosphate by ultrafiltration].
作者信息
Ye Yong, Zhou Li-ling, Yan Yi-lin, Huang Qiu-jie
机构信息
Guangzhou University of Chinese Medicine, China.
出版信息
Zhong Yao Cai. 2010 Aug;33(8):1282-5.
OBJECTIVE
To study the plasma protein binding rate of Tetramethylpyrazine Phosphate.
METHODS
The ultrafiltration was employed to determine the plasma protein binding rate of Tetramethylpyrazine Phosphate. The plasma concentrations of Tetramethylpyrazine Phosphate were measured by RP-HPLC.
RESULTS
The plasma protein binding rate of Tetramethylpyrazine Phosphate with HSA, human plasma and rat plasma were (64.64 +/- 0.68)%, (65.85 +/- 7.35)% and (73.65 +/- 2.35)%, respectively.
CONCLUSION
The binding rate of Tetramethylpyrazine Phosphate with plasma protein is middling strength.
目的
研究磷酸川芎嗪的血浆蛋白结合率。
方法
采用超滤法测定磷酸川芎嗪的血浆蛋白结合率。用反相高效液相色谱法测定磷酸川芎嗪的血浆浓度。
结果
磷酸川芎嗪与人血清白蛋白、人血浆和大鼠血浆的血浆蛋白结合率分别为(64.64±0.68)%、(65.85±7.35)%和(73.65±2.35)%。
结论
磷酸川芎嗪与血浆蛋白的结合率为中等强度。
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