[异亚丙基莽草酸血浆蛋白结合率的测定]
[Determination of plasma protein binding rate of isopropylidene-shikimic acid].
作者信息
Kong Hui, Xing Hongxia, Liu Jin, Yan Lei, Lin Longfei, Ni Jian
机构信息
Beijing University of Chinese Medicine, Beijing 100102, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2012 Jan;37(2):255-7.
OBJECTIVE
To study the plasma protein binding rate of isopropylidene-shikimic acid.
METHOD
The ultrafiltration was employed to determine the plasma protein binding rate of isopropylidene-shikimic acid. The plasma concentrations of isopropylidene-shikimic acid were measured by HPLC.
RESULT
The plasma protein binding rate of isopropylidene-shikimic acid with dog plasma at the concentration of 0.3, 0.15 g x L(-1) and 0.5 mg x L(-1) were (4.36 +/- 0.02)%, (4.12 +/- 0.19)% and (2.23 +/- 0.59)%, respectively. While the plasma protein binding rate of isopropylidene-shikimic acid with normal human plasma at the above concentrations were (11.23 +/- 0.01)%, (10.06 +/- 0.69)% and (9.72 +/- 0.59)%, respectively.
CONCLUSION
The binding rate of isopropylidene-shikimic acid with plasma protein is low.
目的
研究异亚丙基莽草酸的血浆蛋白结合率。
方法
采用超滤法测定异亚丙基莽草酸的血浆蛋白结合率。异亚丙基莽草酸的血浆浓度用高效液相色谱法测定。
结果
异亚丙基莽草酸在浓度为0.3、0.15 g·L⁻¹和0.5 mg·L⁻¹时与犬血浆的血浆蛋白结合率分别为(4.36±0.02)%、(4.12±0.19)%和(2.23±0.59)%。而异亚丙基莽草酸在上述浓度时与正常人血浆的血浆蛋白结合率分别为(11.23±0.01)%、(10.06±0.69)%和(9.72±0.59)%。
结论
异亚丙基莽草酸与血浆蛋白的结合率较低。
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