Penry J K, Dean J C
Department of Neurology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
Epilepsia. 1990;31 Suppl 2:S40-3. doi: 10.1111/j.1528-1157.1990.tb05848.x.
Intermittent stimulation of the vagus nerve in four patients resulted in complete seizure control in two, a 40% reduction of seizure frequency in one, and no change in seizure frequency in the other. Side effects (hoarseness, stimulation sensation in the neck, and hiccups) were transient and occurred concomitantly with stimulation. All patients tolerated increasing stimulation parameters well. The results, however, are inconclusive because of the brief duration (6-12 months) of follow-up. Vagal stimulation represents a novel approach for seizure control in patients who have intractable epilepsy, but additional studies are needed to clarify the efficacy and safety of the procedure and to define selection criteria for patients.
对4例患者进行迷走神经间歇性刺激，结果2例患者癫痫发作得到完全控制，1例患者癫痫发作频率降低了40%，另1例患者癫痫发作频率无变化。副作用（声音嘶哑、颈部刺激感和打嗝）是短暂的，且与刺激同时出现。所有患者对逐渐增加的刺激参数耐受性良好。然而，由于随访时间较短（6 - 12个月），结果尚无定论。迷走神经刺激是一种治疗难治性癫痫患者癫痫发作的新方法，但需要更多研究来阐明该手术的疗效和安全性，并确定患者的选择标准。
