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食品和饲料中三聚氰胺与氰尿酸的毒理学风险

Toxicological risk of melamine and cyanuric acid in food and feed.

作者信息

Suchý Pavel, Straková Eva, Herzig Ivan, Staňa Jaroslav, Kalusová Renata, Pospíchalová Markéta

机构信息

Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

出版信息

Interdiscip Toxicol. 2009 Jun;2(2):55-9. doi: 10.2478/v10102-009-0010-6.

DOI:10.2478/v10102-009-0010-6
PMID:21217848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2984098/
Abstract

From the toxicological point of view, in the last two years melamine and cyanuric acid have become matters of great interest. These substances, especially melamine, have been abused during food and feed adulteration by increasing the content of nitrogen compounds in these products. Melamine and cyanuric acid as individual substances do not pose any serious risk in terms of toxicology. From the point of view of toxicology, it is especially the complex of melamine with cyanuric acid that is important. This complex, also known as the melamine-cyanurate complex, is a cause of human and animal health problems. In this work we present two examples of the incidence of melamine and cyanuric acid in two feed products originating from China. They were rice and the pea concentrates intended for animal nutrition. Protein concentrates can be the main risk factor for food chain contamination with melamine and cyanuric acid, especially those of unknown origin. Feed with a high content of nitrogen compounds and low content of aminoacids can be regarded as particularly suspicious. A comparison of results for determining nitrogen compounds and amines can be used as proof of adulteration of protein feeds. These feeds must be subjected to further analysis to determine melamine and cyanuric acid.

摘要

从毒理学角度来看,在过去两年里,三聚氰胺和氰尿酸已成为备受关注的物质。这些物质,尤其是三聚氰胺,在食品和饲料掺假过程中被滥用,以增加这些产品中氮化合物的含量。三聚氰胺和氰尿酸作为单一物质,在毒理学方面并不构成任何严重风险。从毒理学角度来看,特别重要的是三聚氰胺与氰尿酸的复合物。这种复合物,也被称为三聚氰胺 - 氰尿酸复合物,是导致人类和动物健康问题的原因。在这项工作中,我们展示了源自中国的两种饲料产品中三聚氰胺和氰尿酸出现情况的两个例子。它们是大米和用于动物营养的豌豆浓缩物。蛋白质浓缩物可能是三聚氰胺和氰尿酸污染食物链的主要风险因素,尤其是那些来源不明的产品。氮化合物含量高而氨基酸含量低的饲料可被视为特别可疑。测定氮化合物和胺类的结果比较可作为蛋白质饲料掺假的证据。这些饲料必须进行进一步分析以确定三聚氰胺和氰尿酸。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2854/2984098/11a1a517b4ed/ITX-2-055-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2854/2984098/bdea0a69b836/ITX-2-055-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2854/2984098/11a1a517b4ed/ITX-2-055-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2854/2984098/bdea0a69b836/ITX-2-055-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2854/2984098/11a1a517b4ed/ITX-2-055-g003.jpg

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本文引用的文献

1
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J Am Vet Med Assoc. 2008 Sep 1;233(5):729-37. doi: 10.2460/javma.233.5.729.
2
Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs.宠物食品中导致猫和狗肾毒性爆发的污染物毒性的鉴定与表征。
Toxicol Sci. 2008 Nov;106(1):251-62. doi: 10.1093/toxsci/kfn160. Epub 2008 Aug 9.
3
[Pet food and animal feed contaminated with melamine].
乙酰唑胺对钙转运缺陷小鼠肾小管pH值的调节促进了钙肾结石的形成。
Int J Mol Sci. 2021 Mar 17;22(6):3050. doi: 10.3390/ijms22063050.
4
Swans and elephants: A typology to capture the challenges of food supply chain risk assessment.天鹅与大象:一种用于应对食品供应链风险评估挑战的类型学
Trends Food Sci Technol. 2020 Dec;106:288-297. doi: 10.1016/j.tifs.2020.10.007. Epub 2020 Oct 14.
5
Matting Calcium Crystals by Melamine Improves Stabilization and Prevents Dissolution.用三聚氰胺包覆钙晶体可提高稳定性并防止溶解。
Cryst Growth Des. 2019 Nov 6;19(11):6636-6648. doi: 10.1021/acs.cgd.9b01036. Epub 2019 Oct 14.
6
Aptamer-functionalized AuNPs for the high-sensitivity colorimetric detection of melamine in milk samples.适配体功能化金纳米颗粒用于高灵敏度比色法检测牛奶样品中的三聚氰胺。
PLoS One. 2018 Aug 2;13(8):e0201626. doi: 10.1371/journal.pone.0201626. eCollection 2018.
被三聚氰胺污染的宠物食品和动物饲料
Shokuhin Eiseigaku Zasshi. 2008 Feb;49(1):J-13-6.
4
Assessment of melamine and cyanuric acid toxicity in cats.猫中三聚氰胺和氰尿酸毒性的评估。
J Vet Diagn Invest. 2007 Nov;19(6):616-24. doi: 10.1177/104063870701900602.
5
Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007.2004年和2007年在犬猫中发生的与三聚氰胺和氰尿酸相关的肾衰竭疫情。
J Vet Diagn Invest. 2007 Sep;19(5):525-31. doi: 10.1177/104063870701900510.
6
Rapid and unambiguous identification of melamine in contaminated pet food based on mass spectrometry with four degrees of confirmation.基于具有四级确证的质谱法对受污染宠物食品中的三聚氰胺进行快速且明确的鉴定。
J Anal Toxicol. 2007 Jul-Aug;31(6):304-12. doi: 10.1093/jat/31.6.304.
7
Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation.三聚氰胺诱导F344雄性大鼠膀胱致癌作用:致癌性与尿路结石形成之间的相关性
Carcinogenesis. 1995 Nov;16(11):2773-7. doi: 10.1093/carcin/16.11.2773.
8
Absorption and excretion of cyanuric acid in long-distance swimmers.长距离游泳运动员中氰尿酸的吸收与排泄
Drug Metab Rev. 1982;13(3):499-516. doi: 10.3109/03602538209029992.
9
Urolithiasis and bladder carcinogenicity of melamine in rodents.三聚氰胺在啮齿动物中的尿路结石形成及膀胱致癌性。
Toxicol Appl Pharmacol. 1984 Feb;72(2):292-303. doi: 10.1016/0041-008x(84)90314-4.