间苯三酚：经尿道前列腺电切术后预防膀胱痉挛安全有效
[Phloroglucinol: safe and effective for the prevention of bladder spasm after TURP].
作者信息
Chen Tie-Ding, Wang Yin-Huai, Yang Luo-Yan, Jin Peng, Yuan Jun-Bin, Wu Sheng-Peng, Li Song-Chao
机构信息
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
出版信息
Zhonghua Nan Ke Xue. 2010 Nov;16(11):1004-6.
OBJECTIVE
To evaluate the efficacy of phloroglucinol in preventing bladder spasm after transurethral resection of the prostate (TURP).
METHODS
Using the random sampling method, we assigned 74 cases of TURP into a treatment group (n = 39), given 80 mg phloroglucinol every day for 3 days, and a control group (n = 35), left untreated. Then we observed the frequency, duration and pain of bladder spasm within the 3 days and compared them between the two groups.
RESULTS
The mean frequency, duration and pain visual analogue score of bladder spasm were (4.3 +/- 1.2) times, (7.2 +/- 2.1) min and 3.2 +/- 1.6 respectively in the treatment group, as compared with (7.5 +/- 2.4) times, (15.6 +/- 6.8) min and 4.7 +/- 2.3 in the control, with statistically significant differences between the two groups (P < 0.05). And no obvious adverse reactions were found in the treatment group.
CONCLUSION
Phloroglucinol is safe and effective for the prevention and treatment of bladder spasm following TURP.
目的
评估间苯三酚预防经尿道前列腺电切术（TURP）后膀胱痉挛的疗效。
方法
采用随机抽样法，将74例TURP患者分为治疗组（n = 39），每天给予80mg间苯三酚，共3天；对照组（n = 35），不进行治疗。然后观察两组患者3天内膀胱痉挛的发作频率、持续时间及疼痛情况，并进行比较。
结果
治疗组膀胱痉挛的平均发作频率、持续时间及疼痛视觉模拟评分为（4.3±1.2）次、（7.2±2.1）分钟和3.2±1.6，对照组分别为（7.5±2.4）次、（15.6±6.8）分钟和4.7±2.3，两组间差异有统计学意义（P < 0.05）。治疗组未发现明显不良反应。
结论
间苯三酚预防和治疗TURP术后膀胱痉挛安全有效。
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