Shen Yong-Zhang, Lin Xia, Lin Qiang
Department of Urology, Rizhao People's Hospital, Rizhao 276826, Shandong Province, China.
Zhongguo Zhen Jiu. 2012 May;32(5):404-8.
To evaluate the therapeutic effect of overactive bladder after transurethral resection of prostate (TURP) preventively treated with electroacupuncture and Tolterodine.
One hundred and twenty cases of benign prostate hyperplasia of TURP were randomly divided into an electroacupuncture and medicine group, an electroacupuncture group, a medicine group and a control group, 30 cases in each group. All the patients were treated with TURP under the continuous epidural anesthesia, and the catheter was retained for 5-7 days. In electroacupuncture group, before the surgery of the same day, Huiyang (BL 35), Ciliao (BL 32), Qugu (CV 2) and Huiyin (CV 1) were acupunctured with electroacupuncture for 30 min, once a day, 5-7 days' treatment was applied. In medicine group, Tolterodine Tartrate tablet was taken for 2 mg in the morning of surgery day, twice a day and treatment was applied for 5-7 days. In electroacupuncture and medicine group, the comprehensive therapies above in both electroacupuncture group and medicine group were applied. In control group, Pethidine of 50 mg was given by intramuscular injection when bladder was overactive, combined with Anisodamine injection of 10 mg according to the symptoms. The frequency and lasting time of bladder overactivity were compared within 72 hours after TURP in each group.
After TURP, the frequency of bladder overactivity were 2-4 times a day, and lasted for 5-15 min each time in control group. The frequency and lasting time of bladder overactivity in treatment groups at different time were less than those in control group (P < 0.01, P < 0.001). There was no significant difference in comparison of frequency and lasting time of bladder overactivity between electroacupuncture and medicine group (all P > 0.05). The frequency and lasting time of bladder hyperactivity in electroacupuncture and medicine group were less than those in the electroacupuncture group and the medicine group at 24 hours, 24-48 hours, 48-72 hours after TUPR (P < 0.05, P < 0.01, P < 0.001).
After TURP, early prevention of combined therapy of electroacupuncture and Tolterodine with oral administration is superior to that of electroacupuncture therapy or Tolterodine for overactive bladder treatment, and it is the safe and effective method to treat overactive bladder.
评价电针联合托特罗定预防性治疗经尿道前列腺电切术（TURP）后膀胱过度活动症的疗效。
将120例接受TURP治疗的良性前列腺增生患者随机分为电针药物组、电针组、药物组和对照组，每组30例。所有患者均在连续硬膜外麻醉下接受TURP治疗，术后留置导尿管5 - 7天。电针组于手术当日术前，针刺会阳（BL 35）、次髎（BL 32）、曲骨（CV 2）和会阴（CV 1），采用电针治疗30分钟，每日1次，共治疗5 - 7天。药物组于手术日晨口服酒石酸托特罗定片2mg，每日2次，治疗5 - 7天。电针药物组采用电针组和药物组上述综合疗法。对照组膀胱过度活动时肌内注射哌替啶50mg，并根据症状联合注射山莨菪碱10mg。比较各组TURP术后72小时内膀胱过度活动的频率和持续时间。
TURP术后，对照组膀胱过度活动频率为每日2 - 4次，每次持续5 - 15分钟。各治疗组不同时间点膀胱过度活动的频率和持续时间均低于对照组（P < 0.01，P < 0.001）。电针组与药物组膀胱过度活动频率和持续时间比较差异无统计学意义（均P > 0.05）。电针药物组在TUPR术后24小时、24 - 48小时、48 - 72小时膀胱过度活动的频率和持续时间低于电针组和药物组（P < 0.05，P < 0.01，P < 0.001）。
TURP术后，电针联合口服托特罗定早期预防性联合治疗膀胱过度活动症优于电针治疗或托特罗定单独治疗，是治疗膀胱过度活动症安全有效的方法。
