在用重组干扰素γ全身治疗的瘤型麻风患者中，单核白细胞在真皮内广泛积聚。
Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma.
作者信息
Nathan C, Squires K, Griffo W, Levis W, Varghese M, Job C K, Nusrat A R, Sherwin S, Rappoport S, Sanchez E
机构信息
Department of Medicine, Cornell University Medical College, New York, New York 10021.
出版信息
J Exp Med. 1990 Nov 1;172(5):1509-12. doi: 10.1084/jem.172.5.1509.
Intradermal administration of recombinant interferon gamma (rIFN-gamma) to lepromatous leprosy patients has converted the local histology toward a tuberculoid pattern. However, such changes have been confined to the site of injection. In contrast, in the present study, marked, intradermal accumulation of CD3+, CD4+, CD8+, and CD1a+ T cells and Leu-M5+ mononuclear phagocytes was induced at a distance from the sites of administration, in a dose-dependent manner, by 10 daily intramuscular injections of 10-30 micrograms rIFN-gamma/m2. Mononuclear cell infiltration began within 3 d of onset of rIFN-gamma therapy and persisted at least 8 wk. Intramuscular administration of rIFN-gamma to lepromatous patients receiving concurrent chemotherapy can safely induce widespread histologic features of an upgrading reaction.
向瘤型麻风患者皮内注射重组干扰素γ（rIFN-γ）已使局部组织学转变为结核样型。然而，此类变化仅限于注射部位。相比之下，在本研究中，通过每日10次肌肉注射10 - 30微克rIFN-γ/m²，以剂量依赖方式在距给药部位一定距离处诱导了CD3⁺、CD4⁺、CD8⁺和CD1a⁺ T细胞以及Leu-M5⁺单核吞噬细胞显著的皮内聚集。单核细胞浸润在rIFN-γ治疗开始后3天内开始，并持续至少8周。向同时接受化疗的瘤型患者肌肉注射rIFN-γ可安全地诱导升级反应的广泛组织学特征。
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