肿瘤光疗中的卟啉敏化剂。具有两亲性质的新型二氢卟吩和细菌二氢卟吩类敏化剂。
Porphyrin sensitizers in tumour phototherapy. Novel sensitizers of the chlorin and bacteriochlorin class with amphiphilic properties.
作者信息
Bonnett R, Nizhnik A N, White S G, Berenbaum M C
机构信息
Department of Chemistry, Queen Mary and Westfield College, London U.K.
出版信息
J Photochem Photobiol B. 1990 Jun;6(1-2):29-37. doi: 10.1016/1011-1344(90)85071-4.
PMID:2121938
Abstract
The requirements for activity in a tumour-photosensitizing drug are outlined. A series of metallo tetrasulphonatophthalocyanines are shown to be inactive in an in vivo assay of tumour photosensitization; however, some less water-soluble compounds (hydroxylated derivatives of octaethylchlorin and octaethylbacteriochlorin) are shown to possess promising activity.
摘要
概述了肿瘤光致敏药物的活性要求。一系列金属四磺化酞菁在肿瘤光致敏的体内试验中显示无活性；然而，一些水溶性较低的化合物（八乙基氯卟啉和八乙基细菌叶绿素的羟基化衍生物）显示出有前景的活性。
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