Gurinovich G P, Zorina T E, Melnov S B, Melnova N I, Gurinovich I F, Grubina L A, Sarzhevskaya M V, Cherenkevich S N
Institute of Physics, Byelorus Academy of Sciences, Minsk.
J Photochem Photobiol B. 1992 Apr 15;13(1):51-7. doi: 10.1016/1011-1344(92)80039-x.
Several parameters of chlorin e6 and its derivative chlorin e6 ethylenediamide have been investigated as these compound are potential sensitizers for photodynamic therapy. A study carried out to compare the cellular uptake of the pigments indicates that chlorin e6 ethylenediamide possesses an enhanced affinity for tumour cells and cellular membranes. Comparison of the uptake in induced sarcoma shows that chlorin e6 ethylenediamide is a much better tumour localizer than chlorin e6. The efficiency of phototherapy with chlorin e6 ethylenediamide is higher than that with chlorin e6. These data show the influence of the substitution of the carboxyl groups in chlorin e6 by ester and amide groups on the photosensitizing properties of the pigments.
由于二氢卟吩e6及其衍生物二氢卟吩e6乙二酰胺是光动力疗法的潜在敏化剂，因此对它们的几个参数进行了研究。一项比较这些色素细胞摄取情况的研究表明，二氢卟吩e6乙二酰胺对肿瘤细胞和细胞膜具有更强的亲和力。诱导肉瘤摄取情况的比较表明，二氢卟吩e6乙二酰胺比二氢卟吩e6是更好的肿瘤定位剂。二氢卟吩e6乙二酰胺的光疗效率高于二氢卟吩e6。这些数据显示了二氢卟吩e6中羧基被酯基和酰胺基取代对色素光敏性质的影响。
