Centre for Neuroscience, The University of Melbourne, Victoria, Australia.
Neurochem Int. 2011 Sep;59(3):382-93. doi: 10.1016/j.neuint.2010.12.024. Epub 2011 Jan 8.
Adult neural precursor cells (NPCs) are predominantly located in the subventricular zone (SVZ) of the lateral ventricles or in the subgranular zone of the dentate gyrus. These NPCs produce neuroblasts that normally migrate and integrate into the olfactory bulb and hippocampus, respectively. Following CNS damage due to disease or injury, NPCs can also migrate to the site of damage. Enhancement of NPC migration to sites of neural damage may increase their potential for repair but requires an understanding of processes that regulate basal and injury-induced migration so we can harness this potential. This review highlights the extrinsic factors and major intrinsic signalling pathways that regulate endogenous basal NPC migration to the olfactory bulb and the role of inflammatory mediators and chemokines in disease and injury-induced NPC migration.
成年神经前体细胞（NPCs）主要位于侧脑室的室下区（SVZ）或齿状回的颗粒下层。这些 NPC 产生神经母细胞，通常迁移并分别整合到嗅球和海马体中。在因疾病或损伤导致中枢神经系统（CNS）损伤后，NPC 也可以迁移到损伤部位。增强 NPC 向神经损伤部位的迁移能力可能会增加它们修复的潜力，但需要了解调节基础和损伤诱导的迁移的过程，以便我们能够利用这种潜力。这篇综述强调了调节内源性基础 NPC 向嗅球迁移的外在因素和主要内在信号通路，以及炎症介质和趋化因子在疾病和损伤诱导的 NPC 迁移中的作用。
