Gundelach Jannis, Koch Michael
Department of Neuropharmacology, Center for Cognitive Sciences, University of Bremen, PO Box 330440, 28334, Bremen, Germany.
Exp Brain Res. 2018 Apr;236(4):1181-1191. doi: 10.1007/s00221-018-5209-3. Epub 2018 Feb 21.
Clinical treatment of structural brain damage today is largely limited to symptomatic approaches and the avoidance of secondary injury. However, neuronal precursor cells are constantly produced within specified regions of the mammalian brain throughout life. Here we evaluate the potential of the known chemoattractive properties of the glycoprotein laminin on neuroblasts to relocate the cells into damaged brain areas. Injection of a thin laminin tract, leading from the rostral migratory stream to an excitotoxic lesion within the medial prefrontal cortex of rats, enabled neuroblasts to migrate away from their physiological route towards the olfactory bulb into the lesion site. Once they reached the damaged tissue, they migrated further in a non-uniform orientation within the lesion. Furthermore, our data indicate that the process of diverted migration is still active 6 weeks after the treatment and that at least some of the neuroblasts are capable of maturing into adult neurons.
如今，结构性脑损伤的临床治疗在很大程度上限于对症治疗和避免继发性损伤。然而，在哺乳动物大脑的特定区域，神经元前体细胞在其一生中会持续产生。在此，我们评估糖蛋白层粘连蛋白对神经母细胞已知的化学吸引特性，以将这些细胞重新定位到受损脑区的潜力。在大鼠内侧前额叶皮质内，从吻侧迁移流到兴奋性毒性损伤处注射一条细的层粘连蛋白束，能使神经母细胞从其向嗅球的生理路径迁移至损伤部位。一旦它们到达受损组织，就会在损伤部位以不均匀的方向进一步迁移。此外，我们的数据表明，在治疗后6周，转向迁移过程仍然活跃，并且至少一些神经母细胞能够成熟为成年神经元。
