Oral Biology and Biochemistry Group, Biomedical and Oral Sciences Research Unit (FCT Unit 4062), University of Lisbon School of Dental Medicine, Campus Universitário, 1649-003, Lisbon, Portugal.
Clin Oral Investig. 2012 Feb;16(1):155-63. doi: 10.1007/s00784-010-0491-x. Epub 2011 Jan 8.
The objective of this study is to compare salivary hydrogen peroxide (HP) release kinetics and potential toxicity of systemic exposure of four different whitening products. A double-blind, randomized controlled trial was conducted in a Portuguese dental faculty clinic. Two hundred forty volunteers were randomized to eight intervention groups. Participants were randomly assigned to receive active or placebo applications of one of four different products: Opalescence 10% PF™ (OPL), Vivastyle® 10%™ (VS10%), Vivadent Paint On Plus™ (PO+), and Trés White Supreme™ (TWS). Saliva collection was obtained by established methods at different times. The HP salivary content was determined by a photometric method. Salivary HP variations, total amount of salivary HP, and counts of subjects above the safe daily HP dose were the main outcome measures. All whitening systems significantly released HP to the saliva when compared to placebo, and all showed different release kinetics. The adaptable tray system (TWS) presented a risk increase of 37% [20-54%, 95% confidence interval] when compared to the other systems. The use of an adaptable tray whitening system with higher concentration of HP increases the toxicity potential.
本研究旨在比较四种不同美白产品的唾液双氧水（HP）释放动力学和全身暴露潜在毒性。在葡萄牙一所牙科学院进行了一项双盲、随机对照试验。240 名志愿者被随机分为八组干预组。参与者被随机分配接受四种不同产品的活性或安慰剂应用：Opalescence 10% PF™（OPL）、Vivastyle® 10%™（VS10%）、Vivadent Paint On Plus™（PO+）和 Trés White Supreme™（TWS）。通过既定方法在不同时间采集唾液。通过光度法测定唾液 HP 含量。唾液 HP 变化、唾液 HP 总量和超过每日安全 HP 剂量的受试者计数是主要观察指标。与安慰剂相比，所有美白系统均显著向唾液中释放 HP，且均显示出不同的释放动力学。与其他系统相比，可调节托盘系统（TWS）的风险增加了 37%[20-54%，95%置信区间]。使用含有更高浓度 HP 的可调节托盘美白系统会增加毒性潜力。
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