Grimberg M T, Kruijswijk H, Weijers R N, Kroesbergen J, Van Eijk R, Herbschleb J N
Clin Chim Acta. 1978 Sep 15;88(3):449-59. doi: 10.1016/0009-8981(78)90280-2.
Four cases of newborn infants whose mothers had a low urinary oestrogen excretion during pregnancy are reported. Placental sulphatase deficiency in placental insufficiency were excluded by a dehydroepiandrosterone sulphate loading test. Postnatally, they developed a clinical picture characterized by an inappropriate secretion of cortisol which, by the results of an adrenocorticotrophic hormone stimulation test, appeared to be due to an impairment of adrenocorticotrophic hormone secretion. The prenatal and postnatal steroid metabolism is discussed.
本文报告了4例母亲在孕期尿雌激素排泄量低的新生儿病例。通过硫酸脱氢表雄酮负荷试验排除了胎盘硫酸酯酶缺乏和胎盘功能不全。出生后，他们出现了以皮质醇分泌异常为特征的临床表现，根据促肾上腺皮质激素刺激试验结果，这似乎是由于促肾上腺皮质激素分泌受损所致。本文还讨论了产前和产后的类固醇代谢。
