Taylor N F, Philip R S, Shackleton C H
Br J Obstet Gynaecol. 1980 Dec;87(12):1087-94. doi: 10.1111/j.1471-0528.1980.tb04478.x.
Oestrogen levels in urine from 21 normotensive and 13 hypertensive pregnant women were moderately correlated (r = 0.48) with levels of 3 beta-hydroxy-5-ene steroids (oestrogen precursors) in urine from their infants. In five infants from otherwise normal pregnancies in which oestrogen excretion was very low, levels of 3 beta-hydroxy-5-ene steroids were significantly lower than normal while there was no difference between hypertensives and normals. Levels of urinary cortisol metabolites in the infants were moderately correlated with 3 beta-hydroxy-5-ene steroids (r = 0.55) and were especially low in 2 out of 5 infants in the series suffering from distress during delivery. We conclude that subnormal fetal steroidogenesis rather than reduced placental metabolism is the most common cause of low oestrogen excretion of unknown aetiology. A factor in the increased perinatal risk in this group may be an associated insufficient cortisol synthesis by the fetus.
21名血压正常孕妇和13名高血压孕妇尿液中的雌激素水平与她们婴儿尿液中3β-羟基-5-烯类固醇（雌激素前体）水平呈中度相关（r = 0.48）。在5名其他方面正常妊娠但雌激素排泄极低的婴儿中，3β-羟基-5-烯类固醇水平显著低于正常水平，而高血压孕妇和血压正常孕妇的婴儿之间没有差异。婴儿尿液中皮质醇代谢物水平与3β-羟基-5-烯类固醇呈中度相关（r = 0.55），在该系列中5名分娩时窘迫的婴儿中有2名的皮质醇代谢物水平尤其低。我们得出结论，胎儿类固醇生成异常而非胎盘代谢降低是病因不明的雌激素排泄减少的最常见原因。该组围产期风险增加的一个因素可能是胎儿同时存在皮质醇合成不足。
