Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Microbiol Immunol. 2010 Dec;54(12):754-7. doi: 10.1111/j.1348-0421.2010.00277.x.
Whether administration of total alkaloids from Commelina communis L. (TAC) reduces lung damage in influenza virus-infected mice was investigated. Compared with untreated mice, significantly less severe damage was found in the lungs of mice administered TAC at 8 mg/kg per day for 6 days. TAC significantly decreased viral loads in the lungs. The concentrations of IFN-γ in the serum of TAC-treated mice were significantly lower than those of virus control mice at 4 and 6 days post-infection. The results indicate that TAC imparted partial protection to the mice by reducing pulmonary viral loads and limiting lesions in the lungs.
研究了菥蓂总生物碱（TAC）给药是否减轻流感病毒感染小鼠的肺部损伤。与未治疗的小鼠相比，每天给予 TAC8mg/kg，连续 6 天的小鼠肺部损伤明显较轻。TAC 显著降低肺部的病毒载量。与病毒对照小鼠相比，TAC 处理小鼠的血清 IFN-γ浓度在感染后 4 和 6 天显著降低。结果表明，TAC 通过降低肺部病毒载量和限制肺部病变，对小鼠提供了部分保护。
