Key Laboratory of TCM Resource and Compound Prescription, Ministry of Education, Hubei College of Traditional Chinese Medicine, Wuhan, China.
Arch Virol. 2009;154(11):1837-40. doi: 10.1007/s00705-009-0503-9. Epub 2009 Sep 23.
The antiviral activity of total alkaloids from Commelina communis L. (TAC) against influenza virus A/PR/8/34 (H1N1) was investigated in vitro and in vivo. TAC exhibited an inhibitory action on the growth of influenza virus in Madin-Darby canine kidney cells when added before or after viral infection. In mice infected with influenza virus, orally administered TAC at 8, 16 or 32 mg/kg per day for 6 days significantly increased the survival rate, prolonged the mean survival time and reduced the viral titers in the lung and the lung index, compared with that of the untreated virus control. The results obtained suggest that TAC has a pronounced protective effect against infection by influenza A virus.
研究了鸭跖草总生物碱（TAC）对甲型流感病毒 A/PR/8/34（H1N1）的体外和体内抗病毒活性。TAC 在病毒感染前后加入到 Madin-Darby 犬肾细胞中时，对流感病毒的生长表现出抑制作用。在感染流感病毒的小鼠中，每日口服给予 8、16 或 32mg/kg 的 TAC，连续 6 天，与未治疗的病毒对照组相比，显著提高了存活率，延长了平均存活时间，并降低了肺组织和肺指数中的病毒滴度。结果表明，TAC 对甲型流感病毒感染具有明显的保护作用。
