Nishigaki Takahiko, Ide Yoshihito, Murata Kohei
Dept. of Surgery, Suita Municipal Hospital.
Gan To Kagaku Ryoho. 2010 Nov;37(12):2566-8.
We report 8 cases of hepatic resection after systemic chemotherapy for metastatic colorectal cancer. Three patients had unresectable hepatic lesions, and 5 patients were given neoadjuvant chemotherapy. The mean age was 69 (range: 55-81). Five patients received an oxaliplatin based regimen, 4 patients received irinotecan based regimen and 1 patient received UFT/LV. Four patients were treated with bevacizumab, and 2 patients with cetuximab. Duration of chemotherapy was 12 weeks (the mid range of 7-90 weeks). Six patients were PR, and 2 were SD. Although 1 patient had a minor biliary fistula, no major complications were observed. The duration of postoperative hospital stay was 17 (the average range of 13-22). Our results suggest that preoperative chemotherapy for hepatic resection of metastatic colorectal cancer is safe and has no adverse effect on surgery.
我们报告了8例转移性结直肠癌全身化疗后行肝切除术的病例。3例患者存在不可切除的肝脏病变，5例患者接受了新辅助化疗。平均年龄为69岁（范围：55 - 81岁）。5例患者接受了以奥沙利铂为基础的方案，4例患者接受了以伊立替康为基础的方案，1例患者接受了优福定/亚叶酸钙。4例患者接受了贝伐单抗治疗，2例患者接受了西妥昔单抗治疗。化疗持续时间为12周（范围为7 - 90周的中位数）。6例患者为部分缓解（PR），2例为疾病稳定（SD）。虽然1例患者出现轻微胆瘘，但未观察到严重并发症。术后住院时间为17天（平均范围为13 - 22天）。我们的结果表明，转移性结直肠癌肝切除术前化疗是安全的，对手术没有不良影响。
