Shukla Aparna, Awasthi Shilpi
Department of Anaesthesia and Critical Care, ERA'S Lucknow Medical College, Lucknow, India.
Indian J Anaesth. 2010 Nov;54(6):496-503. doi: 10.4103/0019-5049.72637.
Despite advances in modern medicine, sepsis remains a complex syndrome that has been associated with significant morbidity and mortality. Multiple organ failure associated with sepsis leads to high mortality and morbidity. About 28 - 50% deaths have been reported in patients with sepsis. The number of sepsis patients is increasing, with considerable burden on healthcare facilities. Various factors leading to a rise in the incidence of sepsis are (1) Improvement of diagnostic procedures (2) Increase in the number of immunocompromised patients taking treatment for various autoimmune disease, carcinomas, organ transplantation (3) Advances in intensive procedures (4) Nosocomial infections (5) Extensive use of antibiotics. With the better understanding of sepsis various modalities to modify pathophysiological response of septic patients have developed. Activated protein C and low-dose corticosteroid therapy have been tried in patients, with variable results.
尽管现代医学取得了进展，但脓毒症仍然是一种复杂的综合征，与显著的发病率和死亡率相关。与脓毒症相关的多器官功能衰竭导致高死亡率和发病率。据报道，脓毒症患者的死亡率约为28%-50%。脓毒症患者的数量正在增加，给医疗机构带来了相当大的负担。导致脓毒症发病率上升的各种因素包括：（1）诊断程序的改进；（2）接受各种自身免疫性疾病、癌症、器官移植治疗的免疫功能低下患者数量增加；（3）强化治疗程序的进展；（4）医院感染；（5）抗生素的广泛使用。随着对脓毒症的深入了解，已开发出多种改变脓毒症患者病理生理反应的方法。已在患者中尝试使用活化蛋白C和低剂量皮质类固醇疗法，但结果不一。
