Zhang X P, Wang C, Wu D J, Ma M L, Ou J M
Department of General Surgery, Hangzhou First People's Hospital, Hangzhou, Zhejiang, China.
Methods Find Exp Clin Pharmacol. 2010 Nov;32(9):631-44. doi: 10.1358/mf.2010.32.9.1444768.
The aim of this study was to compare the protective effects of three traditional Chinese herbal medicines (ligustrazine, kakonein and Panax notoginsenosides) on multiple organs in a rat model of severe acute pancreatitis (SAP) and to explore the underlying mechanisms. The mortality rates in all three treated groups were significantly lower than the control group (P < 0.05). All three herbal medicines significantly alleviated the pathological changes in the pancreas, liver and kidney in SAP rats, induced pancreatic acinar cell apoptosis and effectively prevented the apoptosis of cells in the liver and kidney; however, no obvious lung protection was observed. Panax notoginsenosides showed better pancreatic protection than ligustrazine and kakonein, while kakonein displayed a better role in improving liver and kidney function. The protective effects of ligustrazine were somewhat more comprehensive.
本研究旨在比较三种中药（川芎嗪、葛根素和三七总皂苷）对重症急性胰腺炎（SAP）大鼠模型多器官的保护作用，并探讨其潜在机制。三个治疗组的死亡率均显著低于对照组（P<0.05）。三种中药均显著减轻了SAP大鼠胰腺、肝脏和肾脏的病理变化，诱导胰腺腺泡细胞凋亡，并有效防止肝脏和肾脏细胞凋亡；然而，未观察到明显的肺保护作用。三七总皂苷对胰腺的保护作用优于川芎嗪和葛根素，而葛根素在改善肝脏和肾脏功能方面发挥了更好的作用。川芎嗪的保护作用更为全面。
