Department of Otolaryngology, Head and Neck Surgery, University of Nebraska, Medical Center, Nebraska, USA.
Laryngoscope. 2010;120 Suppl 4:S217. doi: 10.1002/lary.21684.
Review largest series of patients treated with transtympanic steroids, including outcomes, steroid dosing and adverse outcomes. Review first reported cases of systemic side effects from transtympanic steroids.
A retrospective case series of 166 patients who underwent placement of transtympanic Silverstein tube with microwick for steroid administration was reviewed.
5/166 patients developed systemic side effects, 9/166 patients developed local side effects. 48/166 (29%) of patients had a persistent perforation after therapy. The percent of patients with improvement as a function of symptoms: hearing loss 42%, tinnitus 56%, vertigo 68%, aural fullness 25% and dysequilibrium 66%.
While our study revealed a significant risk of persistent tympanic membrane perforation, the incidence of systemic and local side effects from transtympanic steroid administration is low.
回顾经鼓室给予类固醇治疗的最大系列患者，包括结局、类固醇剂量和不良结局。回顾首例经鼓室给予类固醇引起全身副作用的病例。
对 166 例行鼓室 Silverstein 管加微管置管以给予类固醇的患者进行回顾性病例系列研究。
5/166 例患者出现全身副作用，9/166 例患者出现局部副作用。48/166（29%）例患者在治疗后出现持续性穿孔。根据症状改善的患者比例：听力损失 42%，耳鸣 56%，眩晕 68%，耳闷 25%，平衡障碍 66%。
尽管我们的研究显示出持续性鼓膜穿孔的显著风险，但经鼓室给予类固醇的全身和局部副作用发生率较低。
