Zamboni G, Cecchettin M, Zoppi G
Eur J Pediatr. 1978 Oct 12;129(3):183-90. doi: 10.1007/BF00442162.
In six infants aged between 4 and 8 months with chronic renal failure, we have studied blood levels of calcium (Ca), phosphorus (P), alkaline phosphatase, immunoreactive parathyroid hormone (PTH), and calcitonin (CT), as well as urinary excretion of Ca, P, hydroxyproline and cyclic AMP under basal conditions and during an infusion of 20 mg/kg of 10% Ca gluconate in normal saline over 4 h. Under basal conditions four infants had normal serum Ca and P values, alkaline phosphatase levels at the upper limit of normal, and very high PTH (range: 1450--2550 pg Eq/ml) and CT (range: 700--1900 pg/ml) levels. The urinary Ca excretion was low, whereas the urinary excretion of P, hydroxyproline and cyclic AMP was high. During Ca infusion, the total serum Ca and CT levels increased, PTH fell without however reaching the normal upper limit, and urinary P and cyclic AMP excretion decreased. In two infants with osteodystrophy and the highest levels of PTH (2900 and 3500 pg Eq/ml respectively) there was no suppression of PTH during Ca infusion.
我们研究了6名年龄在4至8个月的慢性肾衰竭婴儿，在基础状态下以及在4小时内静脉输注20mg/kg的10%葡萄糖酸钙生理盐水溶液期间，其血液中钙（Ca）、磷（P）、碱性磷酸酶、免疫反应性甲状旁腺激素（PTH）和降钙素（CT）的水平，以及尿钙、磷、羟脯氨酸和环磷酸腺苷的排泄情况。基础状态下，4名婴儿血清钙和磷值正常，碱性磷酸酶水平处于正常上限，甲状旁腺激素（范围：1450 - 2550 pg Eq/ml）和降钙素（范围：700 - 1900 pg/ml）水平非常高。尿钙排泄量低，而尿磷、羟脯氨酸和环磷酸腺苷排泄量高。钙剂输注期间，血清总钙和降钙素水平升高，甲状旁腺激素下降，但未达到正常上限，尿磷和环磷酸腺苷排泄量减少。两名患有骨营养不良且甲状旁腺激素水平最高（分别为2900和3500 pg Eq/ml）的婴儿在钙剂输注期间甲状旁腺激素未被抑制。
