Ohara Mamiko, Tsubokura Masaharu, Naoto Hosokawa, Kami Masahiro, Mochizuki Takahiro
Department of Nephrology, Kameda Medical Center, Kamogawa, Japan.
Hum Vaccin. 2011 Jan 1;7(1):56-7. doi: 10.4161/hv.7.1.13459.
We experienced an H1N1 influenza A outbreak among medical staff members who had received a vaccination. To investigate the preventive effects of the H1N1 influenza vaccine on the H1N1 influenza A infection, we examined the data on the medical staff members and patients with confirmed H1N1 influenza A or influenza-like illness retrospectively. Approximately half of the young individuals under 30 years of age developed H1N1 influenza A, while the diagnosis was established in 3% of medical staff over the age of 30 and 0.9% of patients with a median age of 67. The mechanism for association between age and the risk of H1N1 infection is unclear; however, it might have been associated with an age-related increase in the prevalence of neutralizing antibody titers against the 2009 H1N1 influenza A as indicated by previous reports. This study showed that current Japanese H1N1 influenza A vaccine program using one dose of non-adjuvant split-virion 2009 H1N1 vaccine with 7.5 μg hemagglutinin had a limited preventive effect on H1N1 influenza A infection in adults under 30 years of age.
我们在已接种疫苗的医护人员中经历了甲型H1N1流感疫情。为调查甲型H1N1流感疫苗对甲型H1N1流感感染的预防效果，我们回顾性检查了确诊为甲型H1N1流感或流感样疾病的医护人员和患者的数据。30岁以下的年轻人中约有一半感染了甲型H1N1流感，而30岁以上的医护人员中有3%被确诊感染，年龄中位数为67岁的患者中有0.9%被确诊感染。年龄与甲型H1N1感染风险之间的关联机制尚不清楚；然而，如先前报告所示，这可能与中和抗体滴度随年龄增长而升高有关。本研究表明，目前日本使用一剂含7.5μg血凝素的非佐剂裂解病毒2009甲型H1N1流感疫苗的甲型H1N1流感疫苗接种计划，对30岁以下成年人的甲型H1N1流感感染预防效果有限。
