Bachiller D, Rüther U
European Molecular Biology Laboratory, Heidelberg, FRG.
Arch Geschwulstforsch. 1990;60(5):357-60.
We have generated transgenic mouse lines expressing the proto-oncogene c-fos under the control of the interferon inducible Mx promotor. We found low expression in skeletal muscle, brain and salivary glands and a very high expression in spleen, liver, thymus, heart and kidney. Despite this transgenic c-fos expression we have not yet detected any phenotypic changes in these mouse lines.
我们已经构建了在干扰素诱导的Mx启动子控制下表达原癌基因c-fos的转基因小鼠品系。我们发现其在骨骼肌、脑和唾液腺中低表达,而在脾脏、肝脏、胸腺、心脏和肾脏中高表达。尽管有这种转基因c-fos表达,我们尚未在这些小鼠品系中检测到任何表型变化。