韩国人群中 TNFSF15 和 IL23R 与溃疡性结肠炎之间没有关联。

No association between TNFSF15 and IL23R with ulcerative colitis in Koreans.

机构信息

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

J Hum Genet. 2011 Mar;56(3):200-4. doi: 10.1038/jhg.2010.166. Epub 2011 Jan 13.

DOI:10.1038/jhg.2010.166

Abstract

Recent genome-wide association studies have shown that some Crohn's disease (CD)-associated loci also contribute to ulcerative colitis (UC) susceptibility. To understand the genetic relationship between the two forms of inflammatory bowel disease, we investigated the well-established CD-susceptibility genes TNFSF15 (tumor necrosis factor ligand superfamily, member 15) and IL23R in Korean patients with UC. Eight TNFSF15 and five IL23R single-nucleotide polymorphisms were genotyped in 654 patients with UC and in 601 healthy controls. There was no association between TNFSF15 or IL23R variants and UC in Korean individuals, in contrast to previous reports of a shared association of the IL23R gene with both CD and UC in Caucasian individuals. Our data suggest that neither TNFSF15 nor IL23R variants contribute to UC susceptibility in Koreans.

摘要

最近的全基因组关联研究表明，一些克罗恩病（CD）相关基因座也与溃疡性结肠炎（UC）易感性有关。为了了解这两种炎症性肠病之间的遗传关系，我们研究了在韩国 UC 患者中已确立的 CD 易感性基因 TNFSF15（肿瘤坏死因子配体超家族成员 15）和 IL23R。在 654 名 UC 患者和 601 名健康对照者中，对 8 个 TNFSF15 和 5 个 IL23R 单核苷酸多态性进行了基因分型。与之前报道的白种人 IL23R 基因与 CD 和 UC 存在共同关联的情况相反，在韩国人群中，TNFSF15 或 IL23R 变异与 UC 没有关联。我们的数据表明，TNFSF15 和 IL23R 变异均不会导致韩国人 UC 易感性。