TNFSF15基因多态性与克罗恩病和溃疡性结肠炎的保护性关联：一项荟萃分析。

Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis.

作者信息

He Liwen, Chen Jiamin, Sun Jiachen, Peng Junsheng, He Qing

机构信息

Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University. (Guangdong Gastrointestinal Hospital), Guangzhou, Guangdong, People's Republic of China.

Department of Endoscopy, The Sixth Affiliated Hospital of Sun Yat-sen University. (Guangdong Gastrointestinal Hospital), Guangzhou, Guangdong, People's Republic of China.

出版信息

Saudi J Gastroenterol. 2018 Jul-Aug;24(4):201-210. doi: 10.4103/sjg.SJG_5_18.

DOI:10.4103/sjg.SJG_5_18

PMID:29873318

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6080154/

Abstract

BACKGROUND/AIMS: Three extensively investigated polymorphisms (rs3810936, rs7848647, and rs6478108) in tumor necrosis factor super family member 15 (TNFSF15) gene have been implicated in risk for inflammatory bowel disease (IBD). We performed a quantitative synthesis of the evidence to clarify these associations of TNFSF15 polymorphisms with IBD.

MATERIALS AND METHODS

Data were extracted from PubMed and EMBASE, up to March 15, 2018. Meta-analysis was performed by critically reviewing five studies for rs3810936 polymorphism (2251 cases and 2442 controls), four studies for rs7848647 polymorphism (1503 cases and 1816 controls), and four studies for rs6478108 polymorphism (1502 cases and 1817 controls).

RESULTS

Our analysis suggested that rs3810936 polymorphism was significantly associated with decreased risk of Crohn's disease (CD) and ulcerative colitis (UC). For rs7848647 polymorphism, significantly protective association between this polymorphism and CD risk was also observed, but not in UC. For rs6478108 polymorphism, we also detected a significantly protective association with CD risk in all genetic model but not in UC.

CONCLUSIONS

This meta-analysis suggests that TNFSF15 polymorphisms may contribute to genetic susceptibility of IBD.

摘要

背景/目的：肿瘤坏死因子超家族成员15（TNFSF15）基因中的三个经过广泛研究的多态性位点（rs3810936、rs7848647和rs6478108）与炎症性肠病（IBD）的发病风险有关。我们进行了一项证据的定量综合分析，以阐明TNFSF15多态性与IBD的这些关联。

材料与方法

数据来源于截至2018年3月15日的PubMed和EMBASE。通过严格审查五项关于rs3810936多态性的研究（2251例病例和2442例对照）、四项关于rs7848647多态性的研究（1503例病例和1816例对照）以及四项关于rs6478108多态性的研究（1502例病例和1817例对照）进行荟萃分析。

结果

我们的分析表明，rs3810936多态性与克罗恩病（CD）和溃疡性结肠炎（UC）风险降低显著相关。对于rs7848647多态性，也观察到该多态性与CD风险之间存在显著的保护关联，但在UC中未观察到。对于rs6478108多态性，我们在所有遗传模型中也检测到与CD风险存在显著的保护关联，但在UC中未检测到。