LiNC-Laboratorio Interdisciplinar de Neurociencias Clinicas, Departamento de Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
J Clin Exp Neuropsychol. 2011 Jun;33(5):523-31. doi: 10.1080/13803395.2010.535505. Epub 2011 Jan 10.
Cannabis is the most used illicit drug in the world, and its use has been associated with prefrontal cortex (PFC) dysfunction, including deficits in executive functions (EF). Considering that EF may influence treatment outcome, it would be interesting to have a brief neuropsychological battery to assess EF in chronic cannabis users (CCU). In the present study, the Frontal Assessment Battery (FAB), a brief, easy to use neuropsychological instrument aimed to evaluate EF, was used to evaluate cognitive functioning of CCU.
We evaluated 107 abstinent CCU with the FAB and compared with 44 controls matched for age, estimated IQ, and years of education.
CCU performed poorly as compared to controls (FAB total score = 16.53 vs. 17.09, p < .05). CCU had also a poor performance in the Motor Programming subtest (2.47 vs. 2.73, p < .05).
This study examined effects of cannabis in executive functioning and showed evidence that the FAB is sensitive to detect EF deficits in early abstinent chronic cannabis users. Clinical significance of these findings remains to be investigated in further longitudinal studies. FAB may be useful as a screening instrument to evaluate the necessity for a complete neuropsychological assessment in this population.
大麻是世界上使用最广泛的非法药物,其使用与前额叶皮层(PFC)功能障碍有关,包括执行功能(EF)缺陷。考虑到 EF 可能会影响治疗效果,那么有一个简短的神经心理学测试来评估慢性大麻使用者(CCU)的 EF 会很有趣。在本研究中,使用 Frontal Assessment Battery(FAB),一种旨在评估 EF 的简短、易于使用的神经心理学工具,来评估 CCU 的认知功能。
我们评估了 107 名戒断的 CCU,并与 44 名年龄、估计智商和受教育年限匹配的对照组进行比较。
CCU 的表现明显差于对照组(FAB 总分=16.53 比 17.09,p<.05)。CCU 在运动规划子测试中的表现也较差(2.47 比 2.73,p<.05)。
本研究考察了大麻对执行功能的影响,并表明 FAB 能够敏感地检测早期戒断的慢性大麻使用者的 EF 缺陷。这些发现的临床意义仍有待进一步的纵向研究来探讨。FAB 可能是一种有用的筛选工具,用于评估该人群进行全面神经心理学评估的必要性。