Department of Clinical and Developmental Neuropsychology, University of Groningen, The Netherlands.
J Neurol Sci. 2011 Nov 15;310(1-2):172-5. doi: 10.1016/j.jns.2011.07.009. Epub 2011 Jul 31.
Impairments in executive functions (EF) in Parkinson's disease (PD) will have a negative influence on daily life. For the assessment objective and subjective measurement approaches are used. It is however unknown whether these approaches contribute in a different way to the assessment of EF in PD. Thirty-nine PD patients and 24 healthy participants completed the Dysexecutive questionnaire (DEX; subjective measure) and the Frontal Assessment Battery (FAB; objective measure). PD patients showed impaired EF (FAB) and reported more problems with EF in daily life (DEX) than healthy participants. The performance on the FAB could however not be explained by the problems with EF that were reported by PD patients (DEX) and vice versa. In conclusion, not all PD patients who show impairments in EF report them and not all PD patients who report problems with EF in daily life show impairments according to objective measurement. Both measures thus contribute in a different way to the assessment of EF in PD patients. However, it has to be considered that the FAB is not a critical test to assess cognition in PD, since these patients also suffer from posterior abnormalities including memory and visuo-spatial deficits which are strong predictors for PD dementia.
在帕金森病（PD）中，执行功能（EF）的损伤会对日常生活产生负面影响。为此，评估采用了客观和主观的测量方法。然而，目前尚不清楚这些方法是否以不同的方式有助于 PD 患者 EF 的评估。39 名 PD 患者和 24 名健康参与者完成了执行功能障碍问卷（DEX；主观测量）和额叶评估量表（FAB；客观测量）。PD 患者的 EF（FAB）受损，并且报告在日常生活中 EF 存在更多问题（DEX）比健康参与者多。然而，PD 患者报告的 EF 问题（DEX）无法解释 FAB 的表现，反之亦然。总之，并非所有 EF 受损的 PD 患者都会报告这些问题，也并非所有报告日常生活中 EF 问题的 PD 患者都根据客观测量显示存在 EF 损伤。因此，这两种测量方法以不同的方式有助于 PD 患者 EF 的评估。然而，必须考虑到 FAB 并不是评估 PD 患者认知的关键测试，因为这些患者还患有包括记忆和视空间缺陷在内的后部异常，这些异常是 PD 痴呆的强预测因素。
