创伤性脑损伤对 HIV 感染者认知功能和大脑代谢物的影响。
Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals.
机构信息
University of California San Diego, San Diego, CA 92093, USA.
出版信息
J Clin Exp Neuropsychol. 2011 Mar;33(3):326-34. doi: 10.1080/13803395.2010.518140. Epub 2011 Jan 10.
Abstract
We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.
摘要
我们探讨了创伤性脑损伤（TBI）病史对与 HIV（人类免疫缺陷病毒）相关的神经认知并发症的可能增强作用。将有自我报告明确 TBI 病史的 HIV 感染参与者与没有 TBI 病史的 HIV 患者进行比较。两组在相关人口统计学和与 HIV 相关的特征方面相匹配。TBI 组在执行功能和工作记忆方面的缺陷明显更大。N-乙酰天冬氨酸（N-acetylaspartate）是神经元完整性的一个假定标志物，在前额灰质和基底神经节脑区的 TBI 组中明显较低。这些结果表明，TBI 对大脑的影响比 HIV 单独作用更大。一个临床意义是，有 TBI 病史的 HIV 患者可能需要更密切地监测，以增加 HIV 相关神经认知障碍的迹象或症状的风险。
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