Grammatikakis I, Zervoudis S, Kassanos D
3rd Department of Obstetrics and Gynecology, "Attikon" University Hospital, Athens, Greece.
J BUON. 2010 Oct-Dec;15(4):639-46.
Breast cancer is the most common type of cancer among females and the 5th most common cause of cancer death. About 5-10% of breast cancers occur due to gene mutations inherited from mother or father. The molecular basis of breast cancer has been extensively investigated, making gene therapy a potential new therapeutic alternative. Mutation compensation, molecular chemotherapy, proapoptotic gene therapy, antiangiogenic gene therapy, genetic immunopotentiation and genetic modulation of resistance/sensitivity are the main gene therapies used. The combination of gene therapy with chemotherapy or radiation is being investigated in ongoing trials. The purpose of this review was to make a synopsis of the currently existing target therapies in breast cancer.
乳腺癌是女性中最常见的癌症类型，也是癌症死亡的第五大常见原因。约5-10%的乳腺癌是由于从母亲或父亲遗传的基因突变所致。乳腺癌的分子基础已得到广泛研究，这使得基因治疗成为一种潜在的新治疗选择。突变补偿、分子化疗、促凋亡基因治疗、抗血管生成基因治疗、基因免疫增强以及耐药性/敏感性的基因调控是主要使用的基因治疗方法。基因治疗与化疗或放疗的联合应用正在进行临床试验研究。本综述的目的是对目前乳腺癌中现有的靶向治疗进行概述。
