Jane C. Burns and Tomoya Matsubara are at the Department of Pediatrics, University of California-San Diego, La Jolla, CA 92093-0609, USA.
Trends Cardiovasc Med. 1995 Jan-Feb;5(1):3-7. doi: 10.1016/1050-1738(94)00025-Q.
Kawasaki disease (KD) is now the most common cause of acquired heart disease in children in the United States and in Japan. Despite 20 years of research since the first English-language report of KD, the etiology of this disease continues to elude us. The long-term effects of the acute vasculitis on the health of the coronary arteries in adulthood is similarly unknown. A review follows of the progress that has been made in our understanding of the pathogenesis and treatment of this mysterious illness.
川崎病(KD)是目前美国和日本儿童后天性心脏病的最常见病因。尽管自首次英文报道 KD 以来已经开展了 20 年的研究,但该疾病的病因仍然未知。急性血管炎对成年后冠状动脉健康的长期影响同样未知。本文回顾了我们在理解这种神秘疾病的发病机制和治疗方面取得的进展。