霍乱弧菌 O43 外多糖的结构，含有一种新的单糖衍生物，4-(N-乙酰-l-allo 苏氨酸基)-4,6-二脱氧-D-葡萄糖。
Structure of the O-polysaccharide of Vibriocholerae O43 containing a new monosaccharide derivative, 4-(N-acetyl-l-allothreonyl)amino-4,6-dideoxy-D-glucose.
机构信息
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
出版信息
Carbohydr Res. 2011 Feb 15;346(3):430-3. doi: 10.1016/j.carres.2010.12.009. Epub 2010 Dec 17.
The O-polysaccharide of Vibrio cholerae O43 was studied using chemical analyses, triflic acid solvolysis and 2D NMR spectroscopy, including (1)H/(1)H COSY, TOCSY, NOESY and (1)H/(13)C gradient-selected HSQC experiments. The following structure of the tetrasaccharide repeating unit of the polysaccharide was established: →3)-β-D-Quip4NAcyl-(1→3)-α-D-GalpNAcA-(1→4)-α-D-GalpNAc-(1→3)-α-D-QuipNAc-(1→ where D-QuiNAc stands for 2-acetamido-2,6-dideoxy-D-glucose, D-Qui4NAcyl for 4-(N-acetyl-L-allothreonyl)amino-4,6-dideoxy-D-glucose and D-GalNAcA for 2-acetamido-2-deoxy-D-galacturonic acid.
采用化学分析、三氟乙酸解聚及二维 NMR 光谱（包括 1H/1H COSY、TOCSY、NOESY 和 1H/13C 梯度选择 HSQC 实验）研究了霍乱弧菌 O43 的 O-多糖。多糖重复四糖单元的以下结构被确定：→3）-β-D-Qui4NAcyl-（1→3）-α-D-GalpNAcA-（1→4）-α-D-GalpNAc-（1→3）-α-D-QuiNAc-（1→，其中 D-QuiNAc 代表 2-乙酰氨基-2,6-二脱氧-D-葡萄糖，D-Qui4NAcyl 代表 4-（N-乙酰-L-allo 苏氨酸基）氨基-4,6-二脱氧-D-葡萄糖，D-GalNAcA 代表 2-乙酰氨基-2-脱氧-D-半乳糖醛酸。
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