抗黑色素瘤分化相关基因 5 抗体是一种用于诊断和预测与青少年皮肌炎相关的间质性肺病的标志物。
Anti-melanoma differentiation-associated gene 5 antibody is a diagnostic and predictive marker for interstitial lung diseases associated with juvenile dermatomyositis.
机构信息
Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
出版信息
J Pediatr. 2011 Apr;158(4):675-7. doi: 10.1016/j.jpeds.2010.11.033. Epub 2011 Jan 13.
PMID:21232756
Abstract
The presence of the anti-melanoma differentiation-associated gene 5 antibody was evaluated in 13 patients with juvenile dermatomyositis (JDM). The antibody was positive in 5 of the 6 patients with JDM-associated interstitial lung disease (ILD), but not in the 7 patients without ILD. This antibody is a useful marker for early diagnosis of JDM-associated ILD.
摘要
研究者评估了 13 例皮肌炎（DM）患儿血清中抗黑素瘤分化相关基因 5（MDA5）抗体的表达情况。6 例皮肌炎相关间质性肺病（ILD）患儿中 5 例抗体阳性，7 例无ILD 患儿抗体均阴性。该抗体是皮肌炎相关ILD 的早期诊断的有用标志物。
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