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Successful treatment of an anti-MDA5 antibody-positive Juvenile Dermatomyositis patient with refractory interstitial lung disease using tofacitinib.

作者信息

Natoli Valentina, Palmeri Serena, Rebollo-Giménez Ana Isabel, Matucci-Cerinic Caterina, Bocca Paola, Caorsi Roberta, Volpi Stefano, Papa Riccardo, Consolaro Alessandro, Gattorno Marco, Ravelli Angelo, Rosina Silvia

机构信息

Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy.

IRCCS Istituto Giannina Gaslini, Paediatric Rheumatology and Autoinflammatory Diseases Unit, Genoa, Italy.

出版信息

Pediatr Rheumatol Online J. 2025 Feb 25;23(1):22. doi: 10.1186/s12969-024-01044-5.

DOI:10.1186/s12969-024-01044-5
PMID:40001174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11863721/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11863721/d4cdc7d96495/12969_2024_1044_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11863721/5b5eb53e5e98/12969_2024_1044_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11863721/c73105ee923c/12969_2024_1044_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11863721/d4cdc7d96495/12969_2024_1044_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11863721/5b5eb53e5e98/12969_2024_1044_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11863721/c73105ee923c/12969_2024_1044_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11863721/d4cdc7d96495/12969_2024_1044_Fig3_HTML.jpg

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1
Successful treatment of an anti-MDA5 antibody-positive Juvenile Dermatomyositis patient with refractory interstitial lung disease using tofacitinib.使用托法替布成功治疗一名患有难治性间质性肺病的抗MDA5抗体阳性青少年皮肌炎患者。
Pediatr Rheumatol Online J. 2025 Feb 25;23(1):22. doi: 10.1186/s12969-024-01044-5.
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The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis.托法替布治疗抗黑色素瘤分化相关基因 5 抗体阳性皮肌炎相关间质性肺病的疗效和安全性：系统评价和荟萃分析。
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Immun Inflamm Dis. 2023 Jun;11(6):e897. doi: 10.1002/iid3.897.
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Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature.托法替尼治疗抗黑色素瘤分化相关基因 5 抗体阳性的青少年皮肌炎的成功治疗：病例报告及文献复习。
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Efficacy and safety of dose escalation of tofacitinib in refractory anti-MDA5 antibody-positive dermatomyositis.托法替尼递增剂量治疗难治性抗 MDA5 抗体阳性皮肌炎的疗效和安全性。
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本文引用的文献

1
Juvenile idiopathic inflammatory myositis: an update on pathophysiology and clinical care.幼年特发性关节炎：病理生理学和临床治疗的最新进展。
Nat Rev Rheumatol. 2023 Jun;19(6):343-362. doi: 10.1038/s41584-023-00967-9. Epub 2023 May 15.
2
Tofacitinib for new-onset adult patients with anti-melanoma differentiation-associated 5 gene antibody positive dermatomyositis.托法替布治疗抗黑色素瘤分化相关 5 基因抗体阳性成人皮肌炎新发病例。
Clin Rheumatol. 2023 Jul;42(7):1847-1853. doi: 10.1007/s10067-023-06567-y. Epub 2023 Mar 16.
3
Use of Janus kinase inhibitors in dermatomyositis: a systematic literature review.
Janus 激酶抑制剂在皮肌炎中的应用：系统文献综述。
Clin Exp Rheumatol. 2023 Mar;41(2):348-358. doi: 10.55563/clinexprheumatol/hxin6o. Epub 2022 Jun 28.
4
Tofacitinib for refractory interstitial lung diseases in anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis.托法替布治疗抗黑色素瘤分化相关 5 基因抗体阳性皮肌炎的难治性间质性肺病。
Rheumatology (Oxford). 2018 Dec 1;57(12):2114-2119. doi: 10.1093/rheumatology/key188.
5
Anti-melanoma differentiation-associated gene 5 antibody is a diagnostic and predictive marker for interstitial lung diseases associated with juvenile dermatomyositis.抗黑色素瘤分化相关基因 5 抗体是一种用于诊断和预测与青少年皮肌炎相关的间质性肺病的标志物。
J Pediatr. 2011 Apr;158(4):675-7. doi: 10.1016/j.jpeds.2010.11.033. Epub 2011 Jan 13.