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儿科隐匿性肺损伤——胶原病所致发病率的热点。

Undercover lung damage in pediatrics - a hot spot in morbidity caused by collagenoses.

机构信息

Mother and Child Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Faculty of Medicine, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania.

出版信息

Front Immunol. 2024 Jun 27;15:1394690. doi: 10.3389/fimmu.2024.1394690. eCollection 2024.

Abstract

Connective tissue represents the support matrix and the connection between tissues and organs. In its composition, collagen, the major structural protein, is the main component of the skin, bones, tendons and ligaments. Especially at the pediatric age, its damage in the context of pathologies such as systemic lupus erythematosus, scleroderma or dermatomyositis can have a significant negative impact on the development and optimal functioning of the body. The consequences can extend to various structures (e.g., joints, skin, eyes, lungs, heart, kidneys). Of these, we retain and reveal later in our manuscript, mainly the respiratory involvement. Manifested in various forms that can damage the chest wall, pleura, interstitium or vascularization, lung damage in pediatric systemic inflammatory diseases is underdeveloped in the literature compared to that described in adults. Under the threat of severe evolution, sometimes rapidly progressive and leading to death, it is necessary to increase the popularization of information aimed at physiopathological triggering and maintenance mechanisms, diagnostic means, and therapeutic directions among medical specialists. In addition, we emphasize the need for interdisciplinary collaboration, especially between pediatricians, rheumatologists, infectious disease specialists, pulmonologists, and immunologists. Through our narrative review we aimed to bring up to date, in a concise and easy to assimilate, general principles regarding the pulmonary impact of collagenoses using the most recent articles published in international libraries, duplicated by previous articles, of reference for the targeted pathologies.

摘要

结缔组织代表支持基质和组织与器官之间的连接。在其组成中,胶原蛋白是主要的结构蛋白,是皮肤、骨骼、肌腱和韧带的主要成分。特别是在儿科时期,其在系统性红斑狼疮、硬皮病或皮肌炎等疾病的背景下的损伤可能对身体的发育和最佳功能产生重大负面影响。后果可能扩展到各种结构(例如关节、皮肤、眼睛、肺、心脏、肾脏)。在我们的手稿中,我们保留并揭示了其中的主要内容,即呼吸系统的受累。在儿科系统性炎症性疾病中,肺部损伤表现为各种形式,可损害胸壁、胸膜、间质或血管化,与成人描述的肺部损伤相比,其在文献中描述得较少。在严重进展的威胁下,有时进展迅速并导致死亡,有必要增加针对生理病理触发和维持机制、诊断手段以及治疗方向的信息在医学专家中的普及。此外,我们强调需要跨学科合作,特别是儿科医生、风湿病学家、传染病专家、肺科医生和免疫学家之间的合作。通过我们的叙述性综述,我们旨在使用国际图书馆中发表的最新文章,以及针对目标疾病的参考文章重复的最新文章,简明扼要地更新有关胶原病对肺部影响的一般原则。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d93/11236559/6c48d5146a4d/fimmu-15-1394690-g001.jpg

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