胃在大鼠肠胰岛轴中的可能作用。

Possible role of the stomach in enteroinsular axis in rats.

作者信息

Ikeda T, Fujiyama K, Hoshino T, Takeuchi T, Mashiba H, Tominaga M

机构信息

First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.

出版信息

Metabolism. 1990 Dec;39(12):1259-62. doi: 10.1016/0026-0495(90)90180-k.

DOI:10.1016/0026-0495(90)90180-k

PMID:2123280

Abstract

To elucidate the possible role of the stomach in enteroinsular axis, rats had both an inflow gastric cannula and an outflow diversion cannula and a duodenal inflow cannula. The effects of intragastric infusion of glucose (1 mL in 10% solution) or mannitol (1 mL in 10% solution) on blood and plasma insulin responses to subsequent intraduodenal glucose (1.5 g/kg in 10% solution) or amino acids (1.0 g/kg in 10% solution) infusion were investigated. Blood glucose and plasma insulin responses to intraduodenal amino acids were not altered by intragastric infusion of glucose or mannitol. However, higher blood glucose and lower plasma insulin responses to intraduodenal glucose were observed in the rat with intragastric infusion of glucose or mannitol compared with controls (intragastric infusion of distilled water). This phenomenon was abolished in the rat with preadministration of phentolamine. These results suggest that intragastric tonicity may suppress glucose-induced insulin secretion, probably through the alpha-adrenergic mechanism in the rat.

摘要

为阐明胃在肠胰岛轴中可能的作用，给大鼠植入了流入式胃插管、流出式分流插管和十二指肠流入插管。研究了胃内输注葡萄糖（10%溶液1 mL）或甘露醇（10%溶液1 mL）对随后十二指肠内输注葡萄糖（10%溶液1.5 g/kg）或氨基酸（10%溶液1.0 g/kg）时血液和血浆胰岛素反应的影响。胃内输注葡萄糖或甘露醇不会改变对十二指肠内氨基酸的血糖和血浆胰岛素反应。然而，与对照组（胃内输注蒸馏水）相比，胃内输注葡萄糖或甘露醇的大鼠对十二指肠内葡萄糖的血糖反应更高，血浆胰岛素反应更低。预先给予酚妥拉明的大鼠中这种现象消失了。这些结果表明，胃内张力可能通过大鼠体内的α-肾上腺素能机制抑制葡萄糖诱导的胰岛素分泌。