Department of Reproductive Medicine, Endometriosis Center, VU University Medical Center, Amsterdam, The Netherlands.
Am J Med Sci. 2011 Mar;341(3):240-2. doi: 10.1097/MAJ.0b013e31820094da.
Anaphylactic reactions to gonadotropin-releasing hormone (GnRH) agonists are exceedingly rare, but if they occur, they can be life threatening. This case describes a 33-year-old patient with endometriosis who developed an acute allergic reaction on leuprolide (Lucrin) administration. Although skin tests with the replacement goserelin (Zoladex) were negative, usage of this medication resulted in a similar allergic reaction. This is the first case report that shows that, in case of a proven allergy to one GnRH agonist, a switch to another GnRH agonist should not be made even if allergy tests are negative for this medication.
促性腺激素释放激素（GnRH）激动剂的过敏反应极为罕见，但如果发生，可能会危及生命。本病例描述了一名 33 岁子宫内膜异位症患者，在使用亮丙瑞林（Lucrin）时发生急性过敏反应。尽管用替代药物戈舍瑞林（Zoladex）进行皮肤测试为阴性，但使用该药物仍会引起类似的过敏反应。这是首例报告表明，在对一种 GnRH 激动剂有明确过敏的情况下，即使对该药物的过敏测试为阴性，也不应改用另一种 GnRH 激动剂。
